Hyperhomocysteinemia is, as the name implies, a problem of high homocysteine levels in the blood. But that doesn’t really tell you very much, so I’ll explain in more detail. Even though you’ve probably never heard of it, homocysteine is a substance present in everyone’s blood all of the time. However, even though we all have it all of the time, it’s considered a toxic substance, and it must be kept at low levels and under control by adequate B vitamin intake and healthy detoxification processes.
If you have high homocysteine levels, you might not even notice. You’re unlikely to feel bad, and you might have high levels for years before a doctor decides there is a reason to check them. But once it’s discovered that you do have high levels, you should be seriously concerned.
High levels indicate that there is a problem that needs to be corrected as soon as possible. While it’s not clear if excess homocysteine actually causes health problems, it’s absolutely clear that high levels indicate a serious underlying problem that needs to be corrected since these levels are linked with:
"This multitude of relationships between elevated plasma
homocysteine and diseases that afflict the elderly, pregnant
women, and the embryo points to the existence of a common
denominator which may be responsible for these diseases.
Whether this denominator is homocysteine itself or homocysteine
is merely a marker, remains to be determined"
Public health significance of elevated homocysteine
Hyperhomocystenemia is not a random occurrence, there are underlying serious reasons why someone might have a high homocysteine level. The most common of these problems are:
One way to tell for sure if your hypperhomocysteinemia is being caused by Vitamin B12 Deficiency is to look at your MCV Blood Level that is on every standard 'blood count' test that you get from your doctor. If this level is high or borderline high, this indicates a condition called Macrocytic Anemia, a sure sign of Vitamin B12 Deficiency.
The fact that hyperhomocysteinemia is related to Vitamin B12 deficiency, and that "Raised plasma total homocysteine is a strong prognostic marker of future cognitive decline" explains why Mental Changes From Vitamin B12 Deficiency are a serious and unrecognized problem. Eliminating these problems can often lower high homocysteine levels, but unfortunately, studies have not shown that bringing levels back to normal will reduce the risk of problems like heart disease and dementia.
No one is exactly sure why this is the case, but it could be that irreversible damage from high homocysteine levels has been going on for years or decades before the high homocysteine levels have been found, or that there are complex underlying problems that is causing high homocysteine levels that is not solved simply by reducing homocysteine levels.
While no one is exactly sure why the risk for certain diseases does not decrease when high homocysteine levels are reversed, one possible reason is that the MTHFR gene is present, and the proper forms of vitamins are not given that would both reduce homocysteine levels and to help mitigate the problems caused by the gene.
You see, this gene mutation prevents the B vitamins from being converted into their active form into the blood, but only rarely does the gene prevent a COMPLETE conversion of these vitamins. Because of this, it’s possible that taking folate and Vitamin B12 in the forms normally given by doctors, which are generally the improper form for those with the MTHFR gene, allows enough conversion of these vitamins to reduce hyperhomocysteinemia, but that toxic by products from these vitamin deficiencies still remain.
Additionally, the gene also prevents the conversion of B6 into its active form in the blood, but doctors rarely give additional B6 along with their standard prescription of folic acid and Vitamin B12 and almost never do a Vitamin B6 Level. By missing this Vitamin B6 Deficiency, that is actually also Vitamin B6 Toxicity at the same time, and instead focusing on merely reducing homocysteine levels, they could be overlooking a critical piece required to reduce the risk of these diseases.
Therefore, it’s prudent that everyone with high homocysteine levels be checked for the MTHFR gene and be treated appropriately with vitamins that are MTHFR safe. Whether or not this will reduce the risk factors for heart disease, stroke, and dementia still needs further studies, but it’s a prudent measure to take nonetheless. Hyperhomocyteinemia is a problem with serious long-term consequences that anyone with this abnormal blood test result should make every attempt to find the cause of, and to resolve, in order to protect your long-term health.
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