The Right Dosage of Pregnenolone for Adrenal Gland Fatigue

by Gred
(Los Angeles, Ca)

I'm a very healthy 36 years old male - did the Adrenal Saliva Test 2 years ago and it clearly showed adrenal stress - dhea & cortisol levels where very low and it showed some kind of Pregnenolone Steal.

The report from the great smokies recommended me to take pregnenolone - so started taking 100mg first thing in the morning - it helped but not enough - have tried to not to take for some time but fell back to zero - just started again at same dosage - just wanted to know if i can take more than 100mg / day ? like 100mg in the morning & 100mg before sleep - any kind of advice and help would be greatly appreciated...

Comments for The Right Dosage of Pregnenolone for Adrenal Gland Fatigue

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You'll Need a New Test
by: Kerri Knox, RN- The Immune Queen!

Hi Greg,

So I have two thoughts on this. The first is that 2 years ago was too long ago for me to really help you out with your test. You really should get another one. If you're interested, you can order another salivary Adrenal Function Test here and I'd be happy to give you a personalized recommendation for that.

Second thought is that it doesn't sound like anyone has addressed the CAUSE of your adrenal fatigue. So, anyone could give you pregnenolone til the cows come home and it's really just like pouring water into a leaky bucket to try to keep it full.

While everyone is different, I've found that the MOST likely causes of adrenal fatigue are:

Gluten Sensitivity


Intestinal Pathogens

both of which lead to Increased Intestinal Permeability and nutrient deficiencies which leads to overwhelming stress in a big cycle that keeps making your adrenal fatigue worse and your experience of stress worse.

While it's great that you are addressing your adrenal fatigue as it helps to boost your Immune System Health and decrease stress- it's still really just a symptom of problems. And until you address WHY you have adrenal fatigue, then testing and treating your adrenals isn't really worth it.

Kerri Knox RN Immune Health Queen

Kerri Knox, RN- The Immune System Queen
Functional Medicine Practitioner
Immune System

by: greg

Hi Kerri,

Thanx for the reply - I actually thought about the Leaky Gut Syndrome issue because I seem to have malabsorbtion.

It's much better now but not fully healed - couple of years ago had really bad allergies to everything - could not even take any kind of supplement - as soon as I would take the wrong supplement I would sneeze & have sinus problems for hours - the worst side effects were with wine and beer.

Now its much better have been taking glutamine/colostrum/probiotics/aloe vera/acetyl glucosamine/gamma oryzanol - dont know how long it will take for me to heal the leaky gut but I'm on the right track.

Hopefully my adrenals will kick in soon - i also take liver support supplements to flush toxins and estrogen left overs - and advise on your part would be greatly appreciated...

Good. Looks like you're doing well...
by: Kerri Knox, RN- The Immune Queen!

Hi Greg,

Yes, it DOES sound like you are on the right track! I do have a couple of comments. If you haven't tried a Gluten Intolerance Diet yet, I would highly recommend it as that is the #1 cause of Leaky Gut.

And it Would be a great idea to test your adrenals again and to support them. It's VERY useful and can have a direct effect on healing the leaky gut and cut down on the time that it takes in order to heal. As long as you are getting to the cause of the adrenal problems, then it's definitely useful. Plus, it's good to see if you've improved since you've been working on fixing your issues.

The other thing that I find is that nearly everyone with leaky gut and such severe allergies and adrenal issues is that most everyone has some sort of intestinal pathogen. I always insist that my clients get an Intestinal Pathogen Test because it nearly ALWAYS shows some pathogen and it almost always helps people feel better when they get rid of their bug.

So, that would be my $0.02...

Kerri Knox RN Immune Health Queen

Kerri Knox, RN- The Immune System Queen
Functional Medicine Practitioner
Immune System

by: greg

Hi Kerri,

Well I went through all the testing steps that you are talking about - i think my health issue started from a mold infection that build up to candida overgrowth that lead to leaky gut - done the stool test and had minor bacterial infection but nothing major & as far as I know candida cannot be found in stool samples its very hard to locate it.

I don't know about gluten intolerance because I never eat that kind of food - years ago I just had hard time digesting any kind of food - the worst feeling was when I used to drink red wine and beer - that's my testing point when I drink wine and beer I know I'm healing because I don't have side effects anymore from these drinks - took me years to start healing.

The healing process is frustrating and long term - will keep you updated -

thanx for your time!

Greg'g post
by: Anthony

I completely relate to your plight, Gregg. I've had serious problems since 2005 when my adrenals simply crashed leaving me with a systemic candida infection> leaky gut ? severe disbiosis> multiple food, chemical and environmental allergies, depression, insomnia...etc. = chronic fatigue syndrome. I hope you are coming along in your healing. Talk about tired of being sick and tired! I'm now (hopefully) in the final stages of healing and recovery from CFS. It's been my worst nightmare which has robbed me of an active and busy career and life with plans put on hold so long I can no longer relate to what I used to want. I'm hoping to 'reignite' my passions once my energy and desire comes back. Hormones DHEA and low dose cortef seem to be helping me get my body and brain back as well as amino acids.

Stage 3 Adrenal Fatigue
by: Eddie

Hi, I am in stage 3 of adrenal fatigue. I have tried every adaptagen out there, Mega doses of Vitamin C, Zinc, Selenium, meditation, organic diet, grain free, sugar free, legume free, etc. I've seen no improvement in my condition. I have not tried hydrocortisone or pregnenolone. I prefer not to use the HC option, but would like to supplement with pregnenolone. I have had diurnal saliva cortisol tests done two years ago, last year and this year. My cortisol in low during the day and high at night. I believe they call this a reverse curve. Any comments are appreciated.

Adrenal issues
by: Conny

I have had that for many years. Doctors kept giving me thyroid medication, adrenal formula and B complex., kept having issues and taking naps., lately reading this book from doctor Joel Wallach I found that my whole problem has been digestive issues.

So I started taking his supplements like digestive enzymes, fish oil and vitamins and I have felt great. Because bad absorption ruins everything you take or eat. I do still take 15 mg of Pregnenolone a day. I also supplement with a great formula from Sun Ten "Ginseng N. Combination which helps to regulate hormonal imbalances in addition to give energy and a sharp memory.

Feeling great not even think about naps. Have been very productive and active. Hope you feel great soon.

adrenal issues
by: Anonymous

Yes, I have had my entire adrenals shut down. Talk about gut issues, they are there. Getting the gut healed is the trick. If your gut is continuously giving issues, this drains your adrenals. L glutamine is very helpful in helping heal your gut.

I also take probiotics and sometimes use the digestive aids as I no longer need them all the time, but the gut is a huge clue to your adrenals, unless a Dr. has put you on large doses of steroids.

This eventually will cause the pituitary to shut down and then your adrenals will stop working. Be careful with taking steroids.

Adrenal Fatigue
by: Anonymous

I am seeing an Endocrinologist/Integrationist, and I have been very pleased with him! I have adrenal insufficiency, as well as chronic intestinal issues. My inflammatory markers were sky high, among other things. He started with my gut, recommending diverse probiotics with at least 7-8 different strains. He also started me on 30mg of pregnenolone/day, gradually building up to it. Diet is also a major factor with Braggs Apple Cider Vinegar twice daily, 2 tbs. After 2 months, my GI symptoms have resolved, and I am slowly feeling more alert and energetic. I go back to him in another month to reassess. This is no quick fix, and lifestyle changes come hard for me. But I MUST do this for me and my wellbeing!

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