I'm taking mb12 but don't have b12 deficiency

My serum b12 levels are in 700's and my MMA test came back normal. I've been experiencing a constant fatigue symptoms, blurry vision, unbalanced glucose levels (going from 165 after eating sugar or simple carbs down to 60 in 2-3 hours), joint/muscle pain, brain fog, and other chronic symptoms. I had every test known to a medical western doctor, and all seems to come back normal. The only thing that keeps on showing is low Vitamin D.


I have 2 copies of A1298C MTHFR mutation and 2 pregnancy losses. I decided to purchase Methylcobalamin B12 and am taking it everyday in 2,500 mcg doses. It does give me more energy, but I'm still feeling fatigued.

Also, when I tried a small dose of methylfolate, I had several adverse reaction (heart palpitations, sweating, irritability, and generally feeling not well) after being on it for about 4 days.

My questions are: should I continue taking mb12 even though my test results don't show any deficiency? What would be a good dose to take to relieve fatigue that has been lingering for over 6 years? For how long should I stay on it? Would it be wise to add methylfolate despite the side effects?

Thank you so very much for your help.

Comments for I'm taking mb12 but don't have b12 deficiency

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Could be lots of things
by: Kerri Knox, Registered Nurse

You seem to be pinning all of your hopes on this being B12 deficiency. While that could be true, it could also be other things.

First of all, if you want to continue taking B12, then you can read my page on Vitamin B12 Deficiency Treatment. There is no downside to continuing B12 without having a known deficiency. But you may want to see what doses studies have shown relieve fatigue best on that page.

Next, you don't say whether you are treating the Vitamin D Deficiency. That would be imperative as that can cause fatigue and most people are deficient.

Next, look into Gluten Sensitivity as a common cause of fatigue.


Good luck, hope this helps and you feel better soon.


Kerri Knox, RN

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